Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors

A series of quinoline–uracil hybrids (10a–l) has been rationalized and synthesized. The inhibitory activity against hCA isoforms I, II, IX, and XII was explored. Compounds 10a–l demonstrated powerful inhibitory activity against all tested hCA isoforms. Compound 10h displayed the best selectivity pro...

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Bibliographic Details
Main Authors: Al-Mahmoudy, A.M.M (Author), El-Behairy, M.F (Author), El-Kalyoubi, S.A (Author), Ibrahim, T.S (Author), Taher, E.S (Author)
Format: Article
Language:English
Published: MDPI 2022
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