Suzuki–miyaura reactions of (4-bromophenyl)-4,6-dichloropyrimidine through commercially available palladium catalyst: Synthesis, optimization and their structural aspects identification through computational studies

Suzuki–miyaura reactions of (4-bromophenyl)-4,6-dichloropyrimidine through commercially available palladium catalyst: Synthesis, optimization and their structural aspects identification through computational studies

5-(4-bromophenyl)-4,6-dichloropyrimidine was arylated with several aryl/heteroaryl boronic acids via the Suzuki cross-coupling reaction by using Pd(0) catalyst to yield novel pyrimidine analogs (3a-h). It was optimized so that good yields were obtained when 5 mol % Pd(PPh3)4 was used along with K3PO...

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Bibliographic Details
Main Authors: Ahmad, G. (Author), Altaf, A.A (Author), Hashmi, M.A (Author), Kanwal, I. (Author), Malik, A. (Author), Rasool, N. (Author), Shah, S.A.A (Author), Sultan, S. (Author), Zahoor, A.F (Author), Zakaria, Z.A (Author)
Format: Article
Language:English
Published: MDPI AG, 2020
Subjects:
DFT
FMO
Pd catalyst
Reactivity descriptors
Suzuki–Miyaura
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