(+)-Spectaline and Iso-6-Spectaline Induce a Possible Cross-Talk between Autophagy and Apoptosis in Trypanosoma brucei rhodesiense

(+)-Spectaline and Iso-6-Spectaline Induce a Possible Cross-Talk between Autophagy and Apoptosis in Trypanosoma brucei rhodesiense

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In our previous study, two known piperidine alkaloids (+)-spectaline (1) and iso-6-spectaline (2) were isolated from the leaves of Senna spectabilis and showed no toxic effect on L6 cells. In view of the potential use of piperidine alkaloids in S. spectabilis for the treatment of sleeping sickness,...

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Bibliographic Details
Main Authors: Ilham Adenan, Mohd (Author), Lim, K.T (Author), Yeoh, C.Y (Author), Zainuddin, Z. (Author)
Format: Article
Language:English
Published: MDPI AG 2019
Subjects:
(+)-spectaline
African trypanosomiasis
antitrypanosomal activity
antitrypanosomal agent
apoptosis
Apoptosis
Article
Autophagy
autophagy (cellular)
caspase
concentration response
controlled study
Cross-talk
DNA fragmentation
drug exposure
enzyme activation
IC50
iso 6 spectaline
Iso-6-spectaline
mitochondrial membrane potential
nonhuman
piperidine derivative
spectaline
Trypanosoma brucei rhodesiense
unclassified drug
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