Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2

Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2

Lamellarin α 20-sulfate is a cell-impenetrable marine alkaloid that can suppress infection that is mediated by the envelope glycoprotein of human immunodeficiency virus type 1. We explored the antiviral action and mechanisms of this alkaloid against emerging enveloped RNA viruses that use endocytosi...

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Bibliographic Details
Main Authors: Fukuda, T. (Author), Hayashi, H. (Author), Ishibashi, F. (Author), Iwao, M. (Author), Izumida, M. (Author), Kotani, O. (Author), Kubo, Y. (Author), Sato, H. (Author), Smith, C. (Author), Suga, K. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
alkaloid
Alkaloids
antiviral action
Antiviral Agents
antiviral mechanism
antivirus agent
chemistry
COVID-19
dextran sulfate
Dextran Sulfate
docking simulation
Ebola hemorrhagic fever
Ebolavirus
emerging viruses
glycoprotein
Glycoproteins
Hemorrhagic Fever, Ebola
heparin
Heparin
human
Humans
lamellarin α 20-sulfate
marine alkaloid
metabolism
molecular dynamics simulation
pseudotyped lentiviral vector
SARS-CoV-2
virus entry
Virus Internalization
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