Specific Interaction of DARPin with HIV-1 CANTD Disturbs the Distribution of Gag, RNA Packaging, and Tetraspanin Remodelling in the Membrane

Specific Interaction of DARPin with HIV-1 CANTD Disturbs the Distribution of Gag, RNA Packaging, and Tetraspanin Remodelling in the Membrane

A designed repeat scaffold protein (AnkGAG1D4) recognizing the human immunodeficiency virus-1 (HIV-1) capsid (CA) was formerly established with antiviral assembly. Here, we investigated the molecular mechanism of AnkGAG1D4 function during the late stages of the HIV-1 replication cycle. By applying s...

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Bibliographic Details
Main Authors: Chetprayoon, P. (Author), Chupradit, K. (Author), Maniratanachote, R. (Author), Moonmuang, S. (Author), Sornsuwan, K. (Author), Tayapiwatana, C. (Author), Thongkum, W. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
ankyrin
Antiviral Agents
antivirus agent
Capsid
capsid protein
Capsid Proteins
Designed Ankyrin Repeat Proteins
gag Gene Products, Human Immunodeficiency Virus
Gag polyprotein
Gag protein
genetics
HIV-1
human
Human immunodeficiency virus 1
Humans
metabolism
RNA
RNA, Viral
tetraspanin
Tetraspanins
virus assembly
Virus Assembly
virus assembly inhibitor
virus capsid
virus RNA
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