Development of Robust Varicella Zoster Virus Luciferase Reporter Viruses for In Vivo Monitoring of Virus Growth and Its Antiviral Inhibition in Culture, Skin, and Humanized Mice

Development of Robust Varicella Zoster Virus Luciferase Reporter Viruses for In Vivo Monitoring of Virus Growth and Its Antiviral Inhibition in Culture, Skin, and Humanized Mice

There is a continued need to understand varicella-zoster virus (VZV) pathogenesis and to develop more effective antivirals, as it causes chickenpox and zoster. As a human-restricted alphaherpesvirus, the use of human skin in culture and mice is critical in order to reveal the important VZV genes tha...

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Bibliographic Details
Main Authors: Flot, J.S (Author), Geiler, B.W (Author), Kinchington, P.R (Author), Liu, D. (Author), Lloyd, M.G (Author), Moffat, J.F (Author), Yee, M.B (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
animal
Animals
Antiviral Agents
antiviral drugs
antivirus agent
bacterial artificial chromosome
bioluminescence imaging
chickenpox
Chickenpox
DNA replication
DNA Replication
DNA, Viral
genetics
herpes zoster
Herpes Zoster
Herpesvirus 3, Human
human
humanized mice
Humans
luciferase
Luciferases
Mice
Mice, SCID
mouse
ORF57 protein, human herpesvirus 8
pathology
SCID mouse
skin
Skin
skin organ culture
Varicella zoster virus
varicella-zoster virus
viral protein
Viral Regulatory and Accessory Proteins
virus DNA
virus replication
Virus Replication
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