Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids

The achievement of an HIV cure is dependent on the eradication or permanent silencing of HIV-latent viral reservoirs, including the understudied central nervous system (CNS) reservoir. This requires a deep understanding of the molecular mechanisms of HIV's entry into the CNS, latency establishm...

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Bibliographic Details
Main Authors: Berdenis van Berlekom, A. (Author), Boks, M.P (Author), de Witte, L.D (Author), Gharu, L. (Author), Gumbs, S.B.H (Author), Kübler, R. (Author), Nijhuis, M. (Author), Ormel, P.R (Author), Schipper, P.J (Author), Wensing, A.M.J (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
central nervous system
HIV
HIV Infections
HIV-1
HIV-associated neurocognitive disorder
human
Human immunodeficiency virus 1
Human immunodeficiency virus infection
Humans
matrigel
microglia
Microglia
neuropathogenesis
organoid
Organoids
physiology
Receptors, HIV
virus receptor
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