Two Consecutive Prolines in the Fusion Peptide of Murine β-Coronavirus Spike Protein Predominantly Determine Fusogenicity and May Be Essential but Not Sufficient to Cause Demyelination

Two Consecutive Prolines in the Fusion Peptide of Murine β-Coronavirus Spike Protein Predominantly Determine Fusogenicity and May Be Essential but Not Sufficient to Cause Demyelination

Combined in silico, in vitro, and in vivo comparative studies between isogenic-recombinant Mouse-Hepatitis-Virus-RSA59 and its proline deletion mutant, revealed a remarkable contribution of centrally located two consecutive prolines (PP) from Spike protein fusion peptide (FP) in enhancing virus fuso...

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Bibliographic Details
Main Authors: Behera, A. (Author), Das Sarma, J. (Author), Kishore, A. (Author), Maity, D. (Author), Mulchandani, V. (Author), Pal, D. (Author), Safiriyu, A.A (Author), Singh, M. (Author), Sinha, B. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
animal
Animals
cell-to-cell fusion (fusogenicity)
coronavirus spike glycoprotein
demyelinating disease
Demyelinating Diseases
demyelination
fusion peptide/FP
genetics
hepatitis
metabolism
Mice
mouse
mouse hepatitis virus-2/MHV2 spike protein
mouse hepatitis virus-A59/MHV-A59
neuropathogenesis
peptide
Peptides
proline
Proline
Spike Glycoprotein, Coronavirus
structural rigidity
Viral Envelope Proteins
virus envelope protein
β-Coronavirus
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