Identifying Structural Features of Nucleotide Analogues to Overcome SARS-CoV-2 Exonuclease Activity

Identifying Structural Features of Nucleotide Analogues to Overcome SARS-CoV-2 Exonuclease Activity

With the recent global spread of new SARS-CoV-2 variants, there remains an urgent need to develop effective and variant-resistant oral drugs. Recently, we reported in vitro results validating the use of combination drugs targeting both the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and proofread...

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Bibliographic Details
Main Authors: Ju, J. (Author), Kalachikov, S. (Author), Kumar, S. (Author), Li, X. (Author), Morozova, I. (Author), Russo, J.J (Author), Tao, C. (Author), Wang, X. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
antivirals
coronaviruses
exonuclease
nucleotide analogues
RNA-dependent RNA polymerase
SARS-CoV-2
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