HPLC-Based Purification and Isolation of Potent Anti-HIV and Latency Reversing Daphnane Diterpenes from the Medicinal Plant Gnidia sericocephala (Thymelaeaceae)

HPLC-Based Purification and Isolation of Potent Anti-HIV and Latency Reversing Daphnane Diterpenes from the Medicinal Plant Gnidia sericocephala (Thymelaeaceae)

Despite the success of combination antiretroviral therapy (cART), HIV persists in low-and middle-income countries (LMIC) due to emerging drug resistance and insufficient drug accessibility. Furthermore, cART does not target latently-infected CD4+ T cells, which represent a major barrier to HIV eradi...

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Bibliographic Details
Main Authors: Gqaleni, N. (Author), Gyampoh, K. (Author), Invernizzi, L. (Author), Klimkait, T. (Author), Levitties, N. (Author), Maharaj, V. (Author), Montaner, L.J (Author), Mounzer, K. (Author), Moyo, P. (Author), Naidoo-Maharaj, D. (Author), Nkabinde, M. (Author), Nkabinde, S. (Author), Sciorillo, A. (Author), Tembeni, B. (Author), Tietjen, I. (Author), Urda, L. (Author), Yuan, Z. (Author), Zu, G. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
antiretroviral therapy
daphnane-type compounds
Gnidia sericocephala
HIV
HIV in PBMC
protein kinase C activation
reverse HIV latency
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