Synthesis, spectral analysis and biological evaluation of 2-{[(morpholin-4-yl)ethyl]thio}-5-phenyl/aryl-1,3,4-oxadiazole derivatives

Synthesis, spectral analysis and biological evaluation of 2-{[(morpholin-4-yl)ethyl]thio}-5-phenyl/aryl-1,3,4-oxadiazole derivatives

A series of new derivatives of 4-(2-chloroethyl)morpholine hydrochloride (5) were efficiently synthesized. Briefly, different aromatic organic acids (1a-f) were refluxed to acquire respective esters (2a-f) using conc. H2SO4 as catalyst. The esters were subjected to nucleophillic substitution by mono...

Full description

Bibliographic Details
Main Authors: Ahmad, M. (Author), Akhtar, N. (Author), Aziz-Ur-Rehman (Author), Batool, S. (Author), Bokhari, T.H (Author), Irfan, M. (Author), Khan, S.G (Author), Naqvi, S.A.R (Author), Rasool, S. (Author), Shah, S.A.A (Author), Shahid, M. (Author), Usman, A. (Author)
Format: Article
Language:English
Published: Pakistan Journal of Pharmaceutical Sciences 2021
Series:Pakistan Journal of Pharmaceutical Sciences
Subjects:
1,3,4-oxadiazole
2 [[(morpholin 4 yl)ethyl]thio] 5 aryl 1,3,4 oxadiazole derivative
2 [[(morpholin 4 yl)ethyl]thio] 5 phenyl 1,3,4 oxadiazole derivative
antibacterial activity
Antibacterial activity
antiinfective agent
Article
catalyst
controlled study
drug screening
drug synthesis
Gram negative bacterium
Gram positive bacterium
hemolysis
Hemolytic activity
hemolytic agent
minimum inhibitory concentration
Morpholine
nonhuman
nucleophilicity
spectroscopy
substitution reaction
sulfuric acid
unclassified drug
Online Access:View Fulltext in Publisher
View in Scopus

Internet

View Fulltext in Publisher
View in Scopus

Similar Items