Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells

Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells

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Damnacanthal, an anthraquinone compound, is isolated from the roots of Morinda citrifolia L. (noni), which has been used for traditional therapy in several chronic diseases, including cancer. Although noni has long been consumed in Asian and Polynesian countries, the molecular mechanisms by which it...

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Bibliographic Details
Main Authors: Ahmad, S. (Author), Alitheen, N.B (Author), Aziz, M.Y.A (Author), Ho, W.Y (Author), Ismail, N.H (Author), Omar, A.R (Author), Subramani, T. (Author), Yeap, S.K (Author)
Format: Article
Language:English
Published: Spandidos Publications 2014
Subjects:
Anticancer
antineoplastic activity
antiproliferative activity
apoptosis
Apoptosis
article
breast cancer
cancer inhibition
Caspase
caspase 7
cell count
cell cycle arrest
cell viability
controlled study
cytotoxicity
damnacanthal
Damnacanthal
estrogen receptor alpha
flow cytometry
gene activation
gene expression
growth regulation
human
human cell
IC 50
lipocortin 5
MCF-7
P21
P53
potassium iodide
protein Bax
protein bcl 2
protein p21
protein p53
reverse transcription polymerase chain reaction
X linked inhibitor of apoptosis
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