Effects of TNF-α and IL-10-819 T>C single nucleotide polymorphisms on urogenital schistosomiasis in preschool children in Zimbabwe

Effects of TNF-α and IL-10-819 T>C single nucleotide polymorphisms on urogenital schistosomiasis in preschool children in Zimbabwe

Background: Knowledge gaps exist between host genetic factors and susceptibility to schistosomiasis. Objective: This study determined cytokine levels and single nucleotide polymorphisms of tumour necrosis factor (TNF)-α (rs1800629) and interleukin (IL)-10 (rs1800871) and their possible impact on sus...

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Bibliographic Details
Main Authors: Chimponda, T. (Author), Mann, J. (Author), Marume, A. (Author), Mduluza, T. (Author), Mushayi, C. (Author), Vengesai, A. (Author)
Format: Article
Language:English
Published: AOSIS OpenJournals Publishing AOSIS (Pty) Ltd 2021
Subjects:
adenine
agar gel electrophoresis
allele
amplification refractory mutation system polymerase chain reaction
Article
child
controlled study
cross-sectional study
Cytokines
cytosine
female
gene frequency
genotype
guanine
human
infection sensitivity
interleukin 10
major clinical study
male
parasite prevalence
pathogenesis
Polymorphisms
preschool child
Protective immunity
reinfection
sandwich ELISA
Schistosoma haematobium
schistosomiasis
schistosomiasis haematobia
single nucleotide polymorphism
Susceptibility
thymine
tumor necrosis factor
urogenital schistosomiasis
urogenital tract infection
Zimbabwe
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