Syzygium aromaticum ethanol extract reduces AlCl3-induced neurotoxicity in mice brain through regulation of amyloid precursor protein and oxidative stress gene expression

Objective: To investigate the neuroprotective effects of Syzygium aromaticum (S. aromaticum) extract (500 mg/kg) on AlCl3 (300 mg/kg)-induced mouse model of oxidative stress and neurotoxicity. Methods: An ethanolic extract of S. aromaticum seeds was prepared and the active compounds were identified...

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Bibliographic Details
Main Authors:	Ahmed, T. (Author), Ali Shah, S. (Author), Amber, S. (Author), Zahid, S. (Author)
Format:	Article
Language:	English
Published:	Medknow Publications 2018
Subjects:	alcohol Aluminum aluminum chloride amyloid precursor protein Amyloid precursor protein animal experiment animal model animal tissue antioxidant antioxidant activity Article brain cortex controlled study copper zinc superoxide dismutase down regulation DPPH radical scavenging assay drug effect gene expression gene expression regulation hippocampus histopathology male mouse nerve degeneration Neurodegeneration neuroprotection neuroprotective agent neurotoxicity nonhuman nuclear magnetic resonance spectroscopy oxidative stress Oxidative stress peroxiredoxin 6 plant extract polymerase chain reaction priority journal protein expression Syzygium aromaticum extract unclassified drug
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Syzygium aromaticum ethanol extract reduces AlCl3-induced neurotoxicity in mice brain through regulation of amyloid precursor protein and oxidative stress gene expression

Internet

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