A robust enzyme-linked immunosorbent assay to measure serum ramucirumab concentrations

A robust enzyme-linked immunosorbent assay to measure serum ramucirumab concentrations

Aim: Ramucirumab, an anti-VEGFR2 monoclonal antibody, has been approved for the treatment of metastatic gastric and colorectal cancer. An assay measuring ramucirumab serum concentrations was needed to investigate its pharmacokinetics and concentration-response relationship. Results: An ELISA was dev...

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Bibliographic Details
Main Authors: Chautard, R. (Author), Desvignes, C. (Author), Lecomte, T. (Author), Lièvre, A. (Author), Ohresser, M. (Author), Paintaud, G. (Author), Raoul, W. (Author), Ternant, D. (Author)
Format: Article
Language:English
Published: Future Medicine Ltd. 2021
Subjects:
advanced cancer
Antibodies, Monoclonal, Humanized
Article
blood
calibration
colorectal cancer
Colorectal Neoplasms
colorectal tumor
controlled study
cross reaction
drug blood level
drug monitoring
enzyme linked immunosorbent assay
enzyme-linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay
epidermal growth factor receptor antibody
human
Humans
ligand binding
limit of quantitation
measurement accuracy
monoclonal antibody
pharmacokinetics
quality control
ramucirumab
reproducibility
sensitivity analysis
standard
therapeutic drug monitoring
validation study
vasculotropin antibody
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