Inductively coupled plasma mass spectrometry method for plasma and intracellular antimony quantification applied to pharmacokinetics of meglumine antimoniate

Lay abstract Cutaneous leishmaniasis is a disease caused by single-cell parasites in the genus Leishmania which results in painful skin ulcers and is spread by insect bites. Drugs containing antimony are the mainstay therapy for cutaneous leishmaniasis, but if and how the amount of these compounds i...

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Bibliographic Details
Main Authors:	Atkinson, S. (Author), Garay-Baquero, D.J (Author), Giraldo-Parra, L. (Author), Gomez, M.A (Author), McDougall, S. (Author), Navas, A. (Author), Prieto, M.D (Author), Rebellon-Sanchez, D.E (Author)
Format:	Article
Language:	English
Published:	Future Medicine Ltd. 2021
Subjects:	adult antimony Antimony antiprotozoal agent Antiprotozoal Agents aqueous solution Article blood blood sampling cell isolation chemical structure chemistry clinical article clinical feature cohort analysis controlled study digestion drug blood level drug effect drug sensitivity drug stability drug structure female human human cell Humans ICP-MS indium inductively coupled plasma mass spectrometry Leishmania leishmaniasis limit of quantitation male mass spectrometry Mass Spectrometry measurement accuracy measurement precision meglumine antimonate meglumine antimoniate Meglumine Antimoniate Molecular Structure Parasitic Sensitivity Tests PBMCs peripheral blood mononuclear cell pharmacokinetic parameters pharmacokinetics plasma practice guideline skin leishmaniasis tetramethylammonium hydroxide TMAH validated method
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Inductively coupled plasma mass spectrometry method for plasma and intracellular antimony quantification applied to pharmacokinetics of meglumine antimoniate

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