Development of a chromatography-free method for high-throughput MS-based bioanalysis of therapeutic monoclonal antibodies
Aim: Our objective was to test the feasibility of developing an LC-free, MS-based approach for high-throughput bioanalysis of humanized therapeutic monoclonal antibodies. Methodology: A universal tryptic peptide from human IgG1, IgG3 and IgG4 was selected as the surrogate peptide for quantitation. A...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Future Medicine Ltd.
2021
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |