Validation of enantioseparation and quantitation of an active metabolite of abrocitinib in human plasma

Validation of enantioseparation and quantitation of an active metabolite of abrocitinib in human plasma

Aims: A chiral HPLC-MS/MS method for quantitation of an active metabolite (M2) of abrocitinib was validated in human plasma. Methods: Protein precipitation extraction and normal phase LC with baseline separation of five analytes (abrocitinib; isomeric metabolites M1, M2, M3 and M4) were achieved fol...

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Bibliographic Details
Main Authors: Kavetska, O. (Author), Tripathy, S. (Author), Wan, X.K (Author), Wentzel, D. (Author)
Format: Article
Language:English
Published: Future Medicine Ltd. 2021
Subjects:
abrocitinib
abrocitinib metabolite
APCI
Article
bioassay
chirality
controlled study
drug blood level
drug metabolite
drug structure
edetic acid
enantioseparation
extraction
human
human plasma
liquid chromatography-mass spectrometry
mass spectrometry
measurement accuracy
measurement precision
molecular weight
precipitation
pyrimidine derivative
Pyrimidines
sulfonamide
Sulfonamides
validation process
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