Synthesis, characterization, antibacterial, α-glucosidase inhibition and hemolytic studies on some new n-(2,3-Dimethylphenyl)benzenesulfonamide derivatives

Synthesis, characterization, antibacterial, α-glucosidase inhibition and hemolytic studies on some new n-(2,3-Dimethylphenyl)benzenesulfonamide derivatives

Purpose: To synthesize a series of new N-(2,3-dimethylphenyl)benzenesulfonamide derivatives with pharmacological analysis. Methods: N-(2,3-Dimethylphenyl)benzenesulfonamide (3) was synthesized by the reaction between 2,3-dimethylaniline (1) and benzenesulfonyl chloride (2) in aqueous basic medium. C...

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Bibliographic Details
Main Authors: Abbasi, M.A (Author), Ahmad, I. (Author), Ashraf, M. (Author), Aziz-ur-Rehman (Author), Hussain, G. (Author), Islam, M. (Author), Rasool, S. (Author), Rubab, K. (Author), Shah, S.A.A (Author), Shahid, M. (Author)
Format: Article
Language:English
Published: University of Benin 2016
Subjects:
2,3-Dimethylaniline
acarbose
alpha glucosidase inhibitor
ampicillin
antibacterial activity
Antibacterial activity
Anti-enzymatic activity
Article
Bacillus subtilis
bacterial strain
benzenesulfonamide derivative
ciprofloxacin
cytotoxicity
electron impact mass spectrometry
enzyme activity
Escherichia coli
Gram negative bacterium
Gram positive bacterium
hemolysis
Hemolytic activity
IC50
in vitro study
infrared spectroscopy
mass spectrometry
minimum inhibitory concentration
n (2,3 dimethylphenyl)benzenesulfonamide derivative
proton nuclear magnetic resonance
Pseudomonas aeruginosa
Salmonella enterica serovar Typhi
Shigella sonnei
Staphylococcus aureus
Sulfonamides
synthesis
thin layer chromatography
unclassified drug
α-Glucosidase inhibitor
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