Synthesis of 2-{[5-(aralkyl/aryl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(4-methyl-1,3-thiazol-2-yl)acetamides: Novel bi-heterocycles as potential therapeutic agents

Purpose: To evaluate the therapeutic potential of new bi-heterocycles containing a 1,3-thiazole and 1,3,4-oxadiazole in the skeleton against Alzheimer's disease and diabetes, supported by in-silico study. Methods: The synthesis was initiated by the reaction of 4-methyl-1,3-thiazol-2-amine (1) w...

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Main Authors:	Abbasi, M.A (Author), Ashraf, M. (Author), Aziz-Ur-Rehman (Author), Khan, F.A (Author), Lodhi, M.A (Author), Mirza, B. (Author), Ramzan, M.S (Author), Shah, S.A.A (Author), Siddiqui, S.Z (Author)
Format:	Article
Language:	English
Published:	University of Benin 2018
Subjects:	2 [(5 (aralkyl/aryl1,3,4 oxadiazol 2 yl)sulfanyl] n (4 methyl 1,3 thiazol 2 yl) acetamide 2 [(5 benzyl 1,3,4 oxadiazol 2 yl)sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (2 chloro 3,5 dinitrophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (2 chlorophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (2 methoxyphenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (2 methyl 3,5 dinitrophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (2,4 dichlorophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (3 aminophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (3 chlorophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (3,5 dinitrophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (4 aminophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (4 chlorophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (4 hydroxyphenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 2 [[5 (4 methylphenyl) 1,3,4 oxadiazol 2 yl]sulfanyl] n (4 methyl 1,3 thiazol 2 yl)acetamide 4-Methyl-1,3-thiazol-2-amine,1,3,4-Oxadiazole acarbose alpha glucosidase Alzheimer disease Article bioassay Brine shrimp carboxylic acid cholinesterase inhibition Cholinesterases controlled study cytotoxicity assay diabetes mellitus doxorubicin drug design drug development drug synthesis electron impact mass spectrometry enzyme inhibition assay heterocyclic compound IC50 infrared radiation molecular docking n (4 methyl 1,3 thiazol 2 yl) 2 [(5 phenyl 1,3,4 oxadiazol 2 yl)sulfanyl]acetamide n (4 methyl 1,3 thiazol 2 yl) 2 [[5 (2 nitrophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl]acetamide n (4 methyl 1,3 thiazol 2 yl) 2 [[5 (3 nitrophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl]acetamide n (4 methyl 1,3 thiazol 2 yl) 2 [[5 (4 nitrophenyl) 1,3,4 oxadiazol 2 yl]sulfanyl]acetamide n (4 methyl 1,3 thiazol 2 yl) 2 [[5 (naphthalen 1 ylmethyl) 1,3,4 oxadiazol 2 yl]sulfanyl]acetamide physostigmine proton nuclear magnetic resonance thiourea unclassified drug Urease urease inhibitor α-Glucosidase
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Synthesis of 2-{[5-(aralkyl/aryl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(4-methyl-1,3-thiazol-2-yl)acetamides: Novel bi-heterocycles as potential therapeutic agents

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