Synthesis of some new propanamide derivatives bearing 4-piperidinyl-1,3,4-oxadiazole, and their evaluation as promising anticancer agents

Purpose: To sequentially synthesize piperidine-4-carboxylic acid ethyl ester-appended 1,3,4-oxadiazole hybrids and to evaluate them as anticancer agents. Methods: Ethyl 1-[(4-methylphenyl)sulfonyl]-4-piperidinecarboxylate (1) was synthesized from 4-methylbenzenesulfonylchloride (a) and ethyl 4-piper...

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Main Authors:	Abbasi, M.A (Author), Ahtzaz, N. (Author), Aziz-Ur-Rehman (Author), Chohan, T.A (Author), Iqbal, J. (Author), Manzoor, S. (Author), Saleem, S. (Author), Shah, S.A.A (Author), Siddiqui, S.Z (Author), Virk, N.A (Author)
Format:	Article
Language:	English
Published:	University of Benin 2018
Subjects:	1,3,4-Oxadiazole 5 (1 [(4 methylphenyl)sulfonyl] 4 piperidinyl) 1,3,4 oxadiazole 2 thiol Anti-cancer activity antineoplastic activity Article carbon nuclear magnetic resonance doxorubicin drug synthesis ethyl 1 [(4 methylphenyl)sulfonyl] 4 piperidine carbohydrazide ethyl 1 [(4 methylphenyl)sulfonyl] 4 piperidinecarboxylate Ethyl isonipecotate IC50 in vitro study mass spectrometry MTT assay n (2 ethylphenyl) 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide n (2 methoxyphenyl) 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide n (2 methylphenyl) 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide n (2 phenylethyl) 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide n (2,3 dimethylphenyl) 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide n (2,4 dimethylphenyl) 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide n (2,5 dimethylphenyl) 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide n (2,6 dimethylphenyl) 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide n (4 ethylphenyl) 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide n (phenylmethyl) 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide n [2 (4 methoxyphenyl)ethyl] 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide n phenyl 2 [[5 [1 [(4 methylphenyl)sulfonyl] 4 piperidinyl] 1,3,4 oxadiazol 2 yl]thio] propanamide Propanamides propionamide derivative proton nuclear magnetic resonance spectroscopy thin layer chromatography unclassified drug
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Synthesis of some new propanamide derivatives bearing 4-piperidinyl-1,3,4-oxadiazole, and their evaluation as promising anticancer agents

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