Biological screening and docking studies of unique hybrids synthesized by conventional versus microwave-assisted techniques

Purpose: To carry out the synthesis of various hybrids of 1,2,4-triazole in search of potential therapeutic enzyme inhibitory agents, and carry out docking and bovine serum albumin (BSA) binding studies on docking and bovine serum albumin (BSA) binding studies on the hybrids. Methods: The target com...

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Main Authors:	Abbasi, M.A (Author), Ashraf, A. (Author), Aziz-Ur-Rehman (Author), Iqbal, J. (Author), Khalid, H. (Author), Khan, S.U (Author), Laulloo, S.J (Author), Rasool, S. (Author), Shah, S.A.A (Author), Siddiqui, S.Z (Author), Virk, N.A (Author)
Format:	Article
Language:	English
Published:	University of Benin 2019
Subjects:	1,2,4-Triazole 2 [(5 {1 [(4 methoxyphenyl)sulfonyl] 4 piperidinyl} 4 phenyl 4h 1,2,4 triazol 3 yl)sulfanyl] n (2 methylphenyl)acetamide 2 [(5 {1 [(4 methoxyphenyl)sulfonyl] 4 piperidinyl} 4 phenyl 4h 1,2,4 triazol 3 yl)sulfanyl] n (3 methylphenyl)acetamide 2 [(5 {1 [(4 methoxyphenyl)sulfonyl] 4 piperidinyl} 4 phenyl 4h 1,2,4 triazol 3 yl)sulfanyl] n (4 methylphenyl)acetamide antioxidant antioxidant activity Article benzene derivative binding affinity biological activity bovine serum albumin butylated hydroxyanisole Butyrylcholinesterase inhibition carbon nuclear magnetic resonance cholinesterase colorimetry DPPH radical scavenging assay drug synthesis electron impact mass spectrometry enzyme inhibition ethyl 1 [(4 methoxyphenyl)sulfonyl] 4 piperidinecarboxylate ethyl 1 [(4 methoxyphenyl)sulfonyl] piperidin 4 yl) 4 phenyl 4h 1,2,4 triazole 3 thiol ethyl 1 [(4 methoxyphenyl)sulfonyl] piperidine 4 carbohydrazide Ethyl isonipecotate hybrid IC50 microwave assisted extraction molecular docking n (2 ethyl 6 methylphenyl)) 2 [(5 {1 [(4 methoxyphenyl)sulfonyl] 4 piperidinyl} 4 phenyl 4h 1,2,4 triazol 3yl)sulfanyl]acetamide- n (2 ethylphenyl) 2 [(5 {1 [(4 methoxyphenyl)sulfonyl] 4 piperidinyl} 4 phenyl 4h 1,2,4 triazol 3yl)sulfanyl]acetamide- n (2 methoxyphenyl) 2 [(5 {1 [(4 methoxyphenyl)sulfonyl] 4 piperidinyl} 4 phenyl 4h 1,2,4 triazol 3yl)sulfanyl]acetamide- n (4 ethoxyphenyl) 2 [(5 {1 [(4 methoxyphenyl)sulfonyl] 4 piperidinyl} 4 phenyl 4h 1,2,4 triazol 3yl)sulfanyl]acetamide- n (4 ethylphenyl) 2 [(5 {1 [(4 methoxyphenyl)sulfonyl] 4 piperidinyl} 4 phenyl 4h 1,2,4 triazol 3yl)sulfanyl]acetamide- n (5 chloro 2 methoxyphenyl) 2 [(5 {1 [(4 methoxyphenyl)sulfonyl] 4 piperidinyl} 4 phenyl 4h 1,2,4 triazol 3yl)sulfanyl]acetamide- n (substituted) 2 bromoacetamide nuclear magnetic resonance imaging proton nuclear magnetic resonance room temperature thin layer chromatography thiourea unclassified drug urease Urease inhibition
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Biological screening and docking studies of unique hybrids synthesized by conventional versus microwave-assisted techniques

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