Evaluating the impact of Viola spathulata in a rat model of brain ischemia/reperfusion by influencing expression level of caspase-3 and cyclooxygenase-2

Evaluating the impact of Viola spathulata in a rat model of brain ischemia/reperfusion by influencing expression level of caspase-3 and cyclooxygenase-2

Introduction: Focal cerebral ischemia followed by reperfusion causes ischemia/reperfusion (I/R) brain injury. I/R injury is a complex pathophysiological process involving inflammation and apoptosis in neurons. Previous studies reported the anti-inflammatory traits of the family Violaceae. We aimed t...

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Bibliographic Details
Main Authors: Abedinzade, M. (Author), Faezi, M. (Author), Gholipour, A. (Author), Khanaki, K. (Author), Mohammadi, E. (Author), Ramezanpour, M. (Author)
Format: Article
Language:English
Published: Iranian Society of Physiology and Pharmacology 2022
Subjects:
animal experiment
animal model
animal tissue
apoptosis
Article
blood brain barrier
brain ischemia
caspase 3
Caspase 3 (CASP3)
cell survival
complementary DNA
controlled study
cyclooxygenase 2
Cyclooxygenase 2 (COX2)
gene expression
infarct volume
Ischemia
male
mechanical thrombectomy
messenger RNA
microglia
nonhuman
plant
polymerase chain reaction
prostaglandin synthase
protein expression
rat
rat model
reactive oxygen metabolite
Reperfusion
reperfusion injury
reverse transcription polymerase chain reaction
RNA extraction
signal transduction
viola spathulata
Viola spathulata
Western blotting
Wistar rat
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