DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma

Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis, and therapeutic treatment of oral squamous cel...

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Main Authors:	Froemming, G.R.A (Author), Khor, G.H (Author), Omar, E. (Author), Tan, A.C (Author), Tan, S.K (Author), Thomas Abraham, M. (Author), Thong, K.L (Author), Vincent-Chong, V.K (Author), Zain, R.B (Author)
Format:	Article
Language:	English
Subjects:	adult Adult age aged Aged Aged, 80 and over Amidohydrolases article cancer prognosis Carcinoma, Squamous Cell cheek mucosa clinical article controlled study DDAH2 dimethylargininase dimethylarginine dimethylamino hydrolase gene DNA methylation DNA Methylation DNA methylation profiling Dual Specificity Phosphatase 1 dual specificity phosphatase 1 gene DUSP1 female Female Gene Expression Regulation, Neoplastic gingiva human human tissue Humans immunohistochemistry lip male Male microarray analysis Middle Aged mitogen activated protein kinase phosphatase 1 Mouth Neoplasms mouth squamous cell carcinoma Neoplasm Proteins Neoplasm Staging Oral squamous cell carcinoma Oral Squamous Cell Carcinoma overall survival p16 gene polymerase chain reaction promoter hypermethylation Promoter hypermethylation promoter region Promoter Regions, Genetic protein expression Protein expression protein expression. protein p16 sex difference Survival Analysis survival rate tongue tumor localization Tumor Markers, Biological
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DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma

Internet

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