Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation

Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation

The Hippo pathway, a highly conserved signaling cascade that functions as an integrator of molecular signals and biophysical states, ultimately impinges upon the transcription coact-ivator Yes-associated protein 1 (YAP). Hippo-YAP signaling has been shown to play key roles both at the early embryoni...

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Bibliographic Details
Main Authors: Beaudoin, A.J (Author), Brivanlou, A.H (Author), Carroll, T.S (Author), De Santis, R. (Author), Etoc, F. (Author), Gnedeva, K. (Author), Haremaki, T. (Author), Hudspeth, A.J (Author), Kastan, N.R (Author), Laundos, T.L (Author), Luo, J.-D (Author), Piccolo, F.M (Author), Tian, Q. (Author)
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022
Subjects:
cell cycle protein
Cell Cycle Proteins
ectoderm
Ectoderm
genetics
human
Humans
Huntington chorea
Huntington Disease
metabolism
nervous system development
Neurogenesis
neurulation
Neurulation
signal transduction
Signal Transduction
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