Unbiased Proteomics, Histochemistry, and Mitochondrial DNA Copy Number Reveal Better Mitochondrial Health in Muscle of High Functioning Octogenarians

Unbiased Proteomics, Histochemistry, and Mitochondrial DNA Copy Number Reveal Better Mitochondrial Health in Muscle of High Functioning Octogenarians

Background: Master athletes prove that preserving a high level of physical function up to very late in life is possible, but the mechanisms responsible for their high function remain unclear. Methods: We performed muscle biopsies in 15 octogenarian world class track and field masters athletes (MA) a...

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Bibliographic Details
Main Authors: Ferrucci, L. (Author), Filion, M.-E (Author), Hepple, R.T (Author), Lyashkov, A. (Author), Macmillan, N.J (Author), Moaddel, R. (Author), Morais, J.A (Author), Spendiff, S. (Author), Taivassalo, T. (Author), Ubaida-Mohien, C. (Author)
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022
Subjects:
aging
exercise 2
mass spectrometry
Master Athletes
mitochondria
non athletes
nuclear pore
octogenarians
physical activity
proteomics
skeletal muscle
spliceosome
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