De novo-designed transmembrane domains tune engineered receptor functions

De novo-designed transmembrane domains tune engineered receptor functions

De novo-designed receptor transmembrane domains (TMDs) present opportunities for precise control of cellular receptor functions. We developed a de novo design strategy for generating programmed membrane proteins (proMPs): single-pass α-helical TMDs that self-assemble through computationally defined...

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Bibliographic Details
Main Authors: Call, M.E (Author), Call, M.J (Author), Chandler, N.J (Author), Cross, R.S (Author), Davey, A.S (Author), Elazar, A. (Author), Fleishman, S.J (Author), Jenkins, M.R (Author), Nguyen, J.V (Author), Trenker, R. (Author), Weinstein, J.Y (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
CAR T cell
chimeric antigen receptor
de novo design
E. coli
immunology
immunotherapy
inflammation
membrane protein
molecular biophysics
mouse
Rosetta
structural biology
transmembrane
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