Synthesis, enzyme inhibitory kinetics mechanism and computational study of N-(4-methoxyphenethyl)-N-(substituted)- 4-methylbenzenesulfonamides as novel therapeutic agents for Alzheimer's disease

The present study comprises the synthesis of a new series of sulfonamides derived from 4-methoxyphenethylamine (1). The synthesis was initiated by the reaction of 1 with 4-methylbenzenesulfonyl chloride (2) in aqueous sodium carbonate solution at pH 9 to yield N-(4-methoxyphenethyl)-4-methylbenzensu...

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Main Authors:	Abbasi, M.A (Author), Ali Shah, S.A (Author), Aziz-ur-Rehman (Author), Hassan, M. (Author), Raza, H. (Author), Seo, S.Y (Author), Siddiqui, S.Z (Author)
Format:	Article
Language:	English
Published:	PeerJ Inc. 2018
Subjects:	Acetylcholinesterase Alkyl/aralkyl halides Alzheimer disease Article benzenesulfonamide derivative binding affinity carbon nuclear magnetic resonance cholinesterase inhibitor drug mechanism drug synthesis elemental analysis enzyme inhibitor complex human IC50 infrared spectroscopy kinetics molecular docking Molecular docking n (1 butyl) n (4 methoxyphenethyl) 4 methylbenzensulfonamide n (1 heptyl) n (4 methoxyphenethyl) 4 methylbenzensulfonamide n (4 methoxyphenethyl) 4 methyl (2 propyl)benzensulfonamide n (4 methoxyphenethyl) 4 methyl n (1 pentyl)benzensulfonamide n (4 methoxyphenethyl) 4 methyl n (1 propyl)benzensulfonamide n (4 methoxyphenethyl) 4 methyl n (2 methylbenzyl)benzensulfonamide n (4 methoxyphenethyl) 4 methyl n (3 methylbenzyl)benzensulfonamide n (4 methoxyphenethyl) 4 methyl n (3 phenyl 1 propyl)benzensulfonamide n (4 methoxyphenethyl) 4 methyl n (4 methylbenzyl)benzensulfonamide n ethyl n (4 methoxyphenethyl) 4 methylbenzensulfonamide neostigmine methyl sulfate protein targeting proton nuclear magnetic resonance Spectral analysis structure activity relation Sulfonamides unclassified drug
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Synthesis, enzyme inhibitory kinetics mechanism and computational study of N-(4-methoxyphenethyl)-N-(substituted)- 4-methylbenzenesulfonamides as novel therapeutic agents for Alzheimer's disease

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