Amelioration of protein misfolding disease by rapamycin: translation or autophagy?
Rapamycin is an inhibitor of mTOR, a key component of the mTORC1 complex that controls the growth and survival of cells in response to growth factors, nutrients, energy balance and stresses. The downstream targets of mTORC1 include ribosome biogenesis, transcription, translation and macroautophagy....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2008-05.
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| Subjects: | |
| Online Access: | Get fulltext |