Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot
The lectin pathway of complement is activated upon binding of mannan-binding lectin (MBL) or ficolins (FCNs) to their targets. Upon recognition of targets, the MBL-and FCN-associated serine proteases (MASPs) are activated, allowing them to generate the C3 convertase C4b2a. Recent findings indicate t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2010-12-02.
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| Subjects: | |
| Online Access: | Get fulltext |