Prediction of single-nucleotide substitutions that result in exon skipping: identification of a splicing silencer in BRCA1 exon 6
Missense, nonsense and translationally silent mutations can inactivate genes by altering the inclusion of mutant exons in mRNA, but their overall frequency amongst disease-causing exonic substitutions is unknown. Here, we have tested missense and silent mutations deposited in the BRCA1 mutation data...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2011-04.
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| Subjects: | |
| Online Access: | Get fulltext |