Prediction of single-nucleotide substitutions that result in exon skipping: identification of a splicing silencer in BRCA1 exon 6
Missense, nonsense and translationally silent mutations can inactivate genes by altering the inclusion of mutant exons in mRNA, but their overall frequency amongst disease-causing exonic substitutions is unknown. Here, we have tested missense and silent mutations deposited in the BRCA1 mutation data...
Main Authors: | Raponi, Michela (Author), Kralovicova, Jana (Author), Copson, Ellen (Author), Divina, Petr (Author), Eccles, Diana (Author), Johnson, Peter (Author), Baralle, Diana (Author), Vorechovsky, Igor (Author) |
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Format: | Article |
Language: | English |
Published: |
2011-04.
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Subjects: | |
Online Access: | Get fulltext |
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