Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease
Hyperphosphorylation of the microtubule-associated protein tau is a significant determinant in AD (Alzheimer's disease), where it is associated with disrupted axonal transport and probably causes synaptic dysfunction. Although less well studied, hyperphosphorylation has been observed in prion d...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
2010-04.
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Subjects: | |
Online Access: | Get fulltext |