Phosphorylation of RIG-I by casein kinase II inhibits its antiviral response
RIG-I is an intracellular RNA virus sensor that mediates a signaling pathway that triggers the alpha/beta interferon (IFN-?/?) immune defenses. However, the mechanism for regulation of RIG-I activity remains largely unknown. Here we show that RIG-I activity is regulated by phosphorylation and dephos...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2011-01.
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| Subjects: | |
| Online Access: | Get fulltext |