The level of mendione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion
Pancreatic β-cells release insulin in response to elevation of glucose from basal (4-7 mM) to stimulatory (8-16 mM) levels. Metabolism of glucose by the β-cell results in the production of low levels of reactive oxygen intermediates (ROI), such as hydrogen peroxide (H<sub>2</sub>O<sub...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2012-01.
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| Subjects: | |
| Online Access: | Get fulltext |