Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene

Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene

Axons and their synapses distal to an injury undergo rapid Wallerian degeneration, but axons in the C57BL/WldS mouse are protected. The degenerative and protective mechanisms are unknown. We identified the protective gene, which encodes an N-terminal fragment of ubiquitination factor E4B (Ube4b) fus...

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Main Authors: Mack, Till G.A (Author), Reiner, Michael (Author), Beirowski, Bogdan (Author), Mi, Weiqian (Author), Emanelli, Monica (Author), Wagner, Diana (Author), Thomson, Derek (Author), Gillingwater, Tom (Author), Court, Felipe (Author), Conforti, Laura (Author), Fernando, F. Shama (Author), Tarlton, Andrea (Author), Anderssen, Christian (Author), Addicks, Klaus (Author), Magni, Giulio (Author), Ribchester, Richard R. (Author), Perry, V. Hugh (Author), Coleman, Michael P. (Author)
Format: Article
Language:English
Published: 2001-11-19.
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