Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene
Axons and their synapses distal to an injury undergo rapid Wallerian degeneration, but axons in the C57BL/WldS mouse are protected. The degenerative and protective mechanisms are unknown. We identified the protective gene, which encodes an N-terminal fragment of ubiquitination factor E4B (Ube4b) fus...
Main Authors: | Mack, Till G.A (Author), Reiner, Michael (Author), Beirowski, Bogdan (Author), Mi, Weiqian (Author), Emanelli, Monica (Author), Wagner, Diana (Author), Thomson, Derek (Author), Gillingwater, Tom (Author), Court, Felipe (Author), Conforti, Laura (Author), Fernando, F. Shama (Author), Tarlton, Andrea (Author), Anderssen, Christian (Author), Addicks, Klaus (Author), Magni, Giulio (Author), Ribchester, Richard R. (Author), Perry, V. Hugh (Author), Coleman, Michael P. (Author) |
---|---|
Format: | Article |
Language: | English |
Published: |
2001-11-19.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (Wld<sup>S</sup>) nerves
by: Grumme Daniela S, et al.
Published: (2005-02-01) -
Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration
by: Andrea Loreto, et al.
Published: (2020-02-01) -
An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2
by: Yuya Yamagishi, et al.
Published: (2016-10-01) -
Simultaneous single-sample determination of NMNAT isozyme activities in mouse tissues.
by: Giuseppe Orsomando, et al.
Published: (2012-01-01) -
The role of the slow Wallerian degeneration genes in human neurodegeneration
by: Fernando, Francisca Shama
Published: (2003)