The x-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with substrate and three inhibitors

The structures of 5-aminolaevulinic acid dehydratase (ALAD) complexed with substrate (5-aminolaevulinic acid) and three inhibitors: laevulinic acid, succinylacetone and 4-keto-5-aminolaevulinic acid, have been solved at high resolution. The ligands all bind by forming a covalent link with Lys263 at...

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Bibliographic Details
Main Authors: Erskine, P.T (Author), Newbold, R. (Author), Brindley, A.A (Author), Wood, S.P (Author), Shoolingin-Jordan, P.M (Author), Warren, M.J (Author), Cooper, J.B (Author)
Format: Article
Language:English
Published: 2001-09.
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