Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/Mitogen-activated protein kinase and c-Jun terminal kinase

Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/Mitogen-activated protein kinase and c-Jun terminal kinase

Alzheimer's disease (AD) is a disorder of two pathologies: amyloid plaques, the core of which is a peptide derived from the amyloid precursor protein (APP), and neurofibrillary tangles composed of highly phosphorylated tau. Protein kinase C (PKC)is known to increase non-amyloidogenic a-secretas...

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Main Authors: Mudher, A. (Author), Chapman, S. (Author), Richardson, J. (Author), Asuni, A. (Author), Gibb, G. (Author), Pollard, C. (Author), Killick, R. (Author), Iqbal, T. (Author), Raymond, L. (Author), Vamdell, I. (Author), Sheppard, P. (Author), Makoff, A. (Author), Gower, E. (Author), Soden, P.E (Author), Lewis, P. (Author), Murphy, M. (Author), Golde, T.E (Author), Rupniak, H.T (Author), Anderton, B.H (Author), Lovestone, S. (Author)
Format: Article
Language:English
Published: 2001-07-15.
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