A review of mechanistic studies on aromatase (CYP19) and 17?-hydroxylase-17,20-lyase (CYP17)
In the conventional P-450 dependent hydroxylation reaction, the FeIII resting state of the enzyme, by a single electron transfer, is reduced to FeII, which reacts with O2 to produce a FeIII-O-O intermediate. The latter following the transfer of another electron furnishes a ferric-peroxyanion, FeIII-...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
2011-05.
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| Subjects: | |
| Online Access: | Get fulltext |