Nuclear reprogramming: kinetics of cell cycle and metabolic progression as determinants of success

Establishment of totipotency after somatic cell nuclear transfer (NT) requires not only reprogramming of gene expression, but also conversion of the cell cycle from quiescence to the precisely timed sequence of embryonic cleavage. Inadequate adaptation of the somatic nucleus to the embryonic cell cy...

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Main Authors: Balbach, Sebastian Thomas (Author), Esteves, Telma Cristina (Author), Houghton, Franchesca Dawn (Author), Siatkowski, Marcin (Author), Pfeiffer, Martin Johannes (Author), Tsurumi, Chizuko (Author), Kanzler, Benoit (Author), Fuellen, Georg (Author), Boiani, Michele (Author)
Format: Article
Language:English
Published: 2012-04.
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