Novel organic nitrates are potent dilators of large coronary arteries with reduced development of tolerance during long-term infusion in dogs: role of the sulfhydryl moiety
The vasodilator action of organic nitrates can be severely impaired by induction of drug tolerance. A critical depletion of sulfhydryl groups has been proposed to play a key role in impairment of the biotransformation of organic nitrates to nitric oxide (NO). We studied the effects of the new cystei...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
1994-05.
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| Subjects: | |
| Online Access: | Get fulltext |