Cell-produced ?-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
?-Synuclein is central in Parkinson's disease pathogenesis. Although initially ?-synuclein was considered a purely intracellular protein, recent data suggest that it can be detected in the plasma and CSF of humans and in the culture media of neuronal cells. To address a role of secreted ?-synuc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2010-05-19.
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| Subjects: | |
| Online Access: | Get fulltext |