An unexpected and significantly lower hydrogen-bond-donating capacity of fluorohydrins compared to nonfluorinated alcohols. [VIP paper]
Rewriting the rules as fluorination does not always increase hydrogen-bond acidity: while the strongly electron-withdrawing fluorine significantly enhances alcohol H-bond acidity in anti-vicinal fluorohydrins, an intramolecular F???HO interaction overrules completely the inductive effect. This leads...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2012-06-18.
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| Subjects: | |
| Online Access: | Get fulltext |