Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase
A previously determined crystal structure of the ternary complex of trehalose-6-phosphate synthase identified a putative transition state-like arrangement based on validoxylamine A 6?-O-phosphate and uridine diphosphate in the active site. Here linear free energy relationships confirm that these inh...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2011-08.
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| Subjects: | |
| Online Access: | Get fulltext |