DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination
DNA methyltransferase 1 (DNMT1) is the primary enzyme that maintains DNA methylation. We describe a previously unknown mode of regulation of DNMT1 protein stability through the coordinated action of an array of DNMT1-associated proteins. DNMT1 was destabilized by acetylation by the acetyltransferase...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2010-11.
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| Subjects: | |
| Online Access: | Get fulltext |