Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease

Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease

A nitric oxide synthase (NOS)-like activity has been demonstrated in human red blood cells (RBCs), but doubts about its functional significance, isoform identity and disease relevance remain. Using flow cytometry in combination with the NO-imaging probe DAF-FM we find that all blood cells form NO in...

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Main Authors: Cortese-Krott, Miriam M. (Author), Rodriguez-Mateos, Ana (Author), Sansone, Roberto (Author), Kuhnle, Gunter G.C (Author), Thasian-Sivarajah, Sivatharsini (Author), Krenz, Thomas (Author), Horn, Patrick (Author), Krisp, Christoph (Author), Wolters, Dirk (Author), Heiß, Christian (Author), Kroncke, Klaus-Dietrich (Author), Hogg, Neil (Author), Feelisch, Martin (Author), Kelm, Malte (Author)
Format: Article
Language:English
Published: 2012-09-24.
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