Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits

Regulator of G protein signaling (RGS) proteins accelerate GTP hydrolysis by G? subunits and thus facilitate termination of signaling initiated by G protein-coupled receptors (GPCRs). RGS proteins hold great promise as disease intervention points, given their signature role as negative regulators of...

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Main Authors: Soundararajan, M. (Author), Willard, F.S (Author), Kimple, A.J (Author), Turnbull, A.P (Author), Ball, L.J (Author), Schoch, G.A (Author), Gileadi, C. (Author), Fedorov, O.Y (Author), Dowler, E.F (Author), Higman, V.A (Author), Hutsell, S.Q (Author), Sundstrom, M. (Author), Doyle, D.A (Author), Siderovski, D.P (Author)
Format: Article
Language:English
Published: 2008-04-29.
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