CDK/CK1 inhibitors roscovitine and CR8 down-regulate amplified MYCN in neuroblastoma cells

CDK/CK1 inhibitors roscovitine and CR8 down-regulate amplified MYCN in neuroblastoma cells

To understand the mechanisms of action of (R)-roscovitine and (S)-CR8, two related pharmacological inhibitors of cyclin-dependent kinases (CDKs), we applied a variety of '-omics' techniques to the human neuroblastoma SH-SY5Y and IMR32 cell lines: (1) kinase interaction assays, (2) affinity...

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Main Authors: Meijer, L. (Author), Delehouze, C. (Author), Godl, K. (Author), Loaec, N. (Author), Desban, N. (Author), Oumata, N. (Author), Galons, H. (Author), Roumeliotis, Theodoros (Author), Giannopoulou, E.G (Author), Grenet, J. (Author), Twitchell, D. (Author), Lahti, J. (Author), Mouchet, N. (Author), Galibert, M-D (Author), Garbis, Spiros D. (Author), Bruyere, C. (Author)
Format: Article
Language:English
Published: 2013-12-09.
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