Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity
Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims peptides for MHC class I presentation, influencing the degree and specificity of CD8+ T cell responses. Single-nucleotide polymorphisms within the exons encoding ERAP1 are associated with autoimmune diseases and cervical carcinoma, but it is not k...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2013-07-01.
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| Subjects: | |
| Online Access: | Get fulltext |